Inflammation in acute myocardial infarction, impact on ventricular remodeling, and new therapeutic targets

pp. 343-348

Abstract

Ischemic heart disease is the most common cause of heart failure, with a high incidence of heart failure despite early revas cularization and neurohormonal modulation. In the acute myocardial infarction setting, necrotized cardiomyocytes induce activation of the innate immune system, increasing the levels of inflammatory cells to help remove dead cells and initiate a corrective response, which allows for proper scar tissue formation.
A prolonged or expanded inflammatory response after infarction contributes to adverse ventricular remodeling and develop ment of heart failure.
Understanding the inflammatory mechanisms that emerge as a result of myocardial infarction and their impact on adverse remodeling that leads to an increased number of major adverse cardiovascular events makes it possible to understand inflam mation as a therapy target.

Key words: Acute Myocardial Infarction - Inflammation - Ventricular Remodeling

How to cite this article

Moreno A, Rodríguez Granillo AM, Pérez de ña Hoz R. Inflammation in Acute Myocardial Infarction, Impact on Ventricular Remodeling, and New Therapeutic Targets. Rev Argent Cardiol 2023;91:343-8. http://dx.doi.org/10.7775/rac.v91.i5.20669