Which should be the goals of apolipoprotein A1? Analysis of a healthy population in Argentina

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Abstract

Background: Recent studies have demonstrated that apolipoprotein A1 (ApoA) is a better predictor of cardiovascular risk than HDL-C. However, the definite goals of this new marker have not been clearly defined.
Objective: The objective of this study was to infer the goals of ApoA from a healthy population.
Methods: The distribution of ApoA and HDL-C in 304 blood donors was analyzed according to gender. ApoA goals were assumed using two strategies: 1) a simple linear regression model, and 2) percentile analyses.
Results: In the percentile analyses, ApoA levels of 126 and 147 mg/dL corresponded to recommended goals for HDL-C in men and women, respectively. The linear regression model showed that 40 and 50 mg/dL HDL-C corresponded to 140 and 158 mg/dL ApoA in men and women, respectively.
Conclusion: The findings of this study suggest that previously postulated ApoA goals should be reviewed in both genders.